PRIMARY DISABILITY DUE TO LIVER CIRROSIS IN THE GOMEL REGION
Abstract
Background. Liver cirrhosis (LC) develops as the outcome of various diseases - viral hepatitis, alcoholic liver disease, autoimmune lesions and others. The delayed diagnosis of the disease often leads to persistent disability of patients.
Objective – to analyze the indicators of disability due to LC in the adult population of the Gomel region over the period of 2014-2018.
Material and methods. We analyzed 291 medical rehabilitation expert commission findings issued to patients over 18 years old, first recognized as disabled due to LC, over 2014-2018.
Results. The percentage of disability due to LC in general structure of primary disability in the Gomel region amounted to 0.66% on average over 2014-2018. Most often, LC leads to disability in the age group of 40-69 (83.7%), working-age people predominating more among men (81.9%) than women (59.4%, p <0.001). The percentage of working-age people recognized as disabled due to LC averaged 54.2% over 5 years. The severity rate of LC totaled 52.9% over 2014-2018. In the etiological structure of LC, the proportion of alcoholic LC is extremely low (less than 3%), while that of unspecified etiology exceeds 55%.
Conclusion. More than half of people with disabilities due to LC are of working age. The severity rate of LC amounted to 52.9% indicating the delayed diagnosis of LC (already at decompensated stage) in half of patients with the resulting loss of rehabilitation potential. It is necessary to improve etiological diagnosis of this pathology.
References
1. Romanelli RG, Stasi C. Recent Advancements in Diagnosis and Therapy of Liver Cirrhosis. Current Drug Targets. 2016;17(15):1804-1817. doi: 10.2174/1389450117666160613101413.
2. Kaffe E, Magkrioti C, Aidinis V. Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer. Cancers (Basel). 2019;11(11):1626. doi: 10.3390/cancers11111626.
3. Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe: a review of available epidemiological data. Journal of Hepatology. 2013;58(3):593-608. doi: 10.1016/j.jhep.2012.12.00.
4. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. Journal of Hepatology. 2019;70(1):151-171. doi: 10.1016/j.jhep.2018.09.014.
5. Jang CM, Jung YK. Hyponatremia in Liver Cirrhosis. Korean Journal of Gastroenterology. 2018;72(2):74-78. doi: 10.4166/kjg.2018.72.2.74.
6. Fukui H, Saito H, Ueno Y, Uto H, Obara K, Sakaida I, Shibuya A, Seike M, Nagoshi S, Segawa M, Tsubouchi H, Moriwaki H, Kato A, Hashimoto E, Michitaka K, Murawaki T, Sugano K, Watanabe M, Shimosegawa T. Evidence-based clinical practice guidelines for liver cirrhosis 2015. Journal of Hepatology. 2016;51(7):629-650. doi: 10.1007/s00535-016-1216-y.
7. Jung YK, Yim HJ. Reversal of liver cirrhosis: current evidence and expectations. Korean Journal of Internal Medicine. 2017;32(2):213-228. doi: 10.3904/kjim.2016. 268.
8. World Health Organization. Regional Office for Europe. Global hepatitis report, 2017 [Internet]. Geneva: WHO; 2017. 83 p. Available from: https://www.who.int/hepatitis/publications/global-hepatitis-report2017/en.
9. Hatzakis A, Wait S, Bruix J, Buti M, Carballo M, Cavaleri M, Colombo M, Delarocque-Astagneau E, Dusheiko G, Esmat G, Esteban R, Goldberg D, Gore C, Lok AS, Manns M, Marcellin P, Papatheodoridis G, Peterle A, Prati D, Piorkowsky N, Rizzetto M, Roudot-Thoraval F, Soriano V, Thomas HC, Thursz M, et al. The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference. Journal of Viral Hepatitis. 2011;18(Suppl 1):1-16. doi:10.1111/j.1365-2893.2011.01499.x.
10. World Health Organization. Regional Office for Europe. European status report on alcohol and health [Internet]. Geneva: WHO; 2018. 472 p. Available from: https://apps.who. int/iris/bitstream/handle/10665/274603/9789241565639-eng.pdf?ua=1.
11. Public Health in The Republic of Belarus An official statistics collection, 2017 [Internet]. Minsk: Republican Scientific Medical Library; 2018. 274 p. Available from: http://rnpcmt.belcmt.by/files/Stat/Healthcare_in_RB_2017.pdf. (Russian).
12. National Statistical Committee of the Republic of Belarus. Healthcare [Internet]. Available from: http://www.belstat.gov.by/ofitsialnaya-statistika/ solialnaya-sfera/zdravoohranenie_2/. (Russian).
13. Razvodovskij JuE. Potreblenie alkogolja i smertnost ot cirroza pecheni v Belarusi. Medicinskaja panorama. 2012;5:37-39. (Russian).
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