MORPHOFUNCTIONAL CHARACTERISTICS OF MAST CELLS OF THE SMALL INTESTINE MUCOSA IN 15- AND 45-DAY RATS BORN TO MOTHERS WITH CHOLESTASIS AND SUBJECTED TO URSODEOXYCHOLIC ACID
Abstract
Background. Mast cells participate in any adaptive reactions and pathological processes of the body. They are found in large numbers in the organs of digestion, respiration, urinary system and fasciae.
Objective. To study the morphofunctional properties of mast cells in the small intestine of rats born to mothers with endogenous intoxication due to cholestasis and subjected to UDCA.
Materials and methods. The experiment was performed on 68 rats aged 15 and 45 days. Histological and histochemical methods were used, followed by morphometric and statistical analysis.
Results. Experimental subhepatic cholestasis, modeled on the 17th day of pregnancy lead to a significant increase not only in the total number of mast cells but also in the number of moderately and completely degranulated forms of these cells in the small intestine mucosa of 45-day-old rats.
Conclusion. Administration of UDCA at a dose of 50 mg/kg to pregnant female rats from the moment of modeling in them cholestasis and within 7 days after delivery, largely neutralizes in their offspring the revealed changes in mast cells.
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